Product Description
High-purity N-methylformamide is a colorless, clear, viscous liquid. Its key physical parameters include a melting point of −3.8 °C, a boiling point of 198 °C, a refractive index (n₂₅ᴰ) of 1.4310, and a relative density of 0.9986 at 25 °C.
It dissolves well in water and inorganic salts, suiting it for multiple chemical processing uses. The compound is hygroscopic and prone to decomposition under acidic or alkaline environments.
Chemical Properties
| Melting point | -4 °C (lit.) |
| Boiling point | 198-199 °C (lit.) |
| Density | 1.011 g/mL at 25 °C (lit.) |
| Vapor pressure | 20Pa at 20℃ |
| Refractive index | n20/D 1.432(lit.) |
| Fp | >230 °F |
| Storage temp | Sealed in dry,Room Temperature |
| Solubility | soluble in water, chloroform, alcohols, acetone, ethylacetate but not in diethyl ether and petroleum ether |
| Pka | 16.48±0.23(Predicted) |
| Form | Liquid |
| Color | Clear colorless |
| Relative polarity | 6.2 |
| Odor | strong odor |
| Water Solubility | miscible |
| Merck | 146076 |
| BRN | 1098352 |
| Exposure limits | ACGIH: TWA 1 ppm (Skin) |
| Dielectric constant | 171 |
| InChIKey | ATHHXGZTWNVVOU-UHFFFAOYSA-N |
| LogP | -0.97 |
| CAS DataBase Reference | 123-39-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Formamide, N-methyl-(123-39-7) |
| EPA Substance Registry System | N-Methylformamide (123-39-7) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 61-21-R61-R21 |
| Safety Statements | 53-45-S53-S45 |
| WGK Germany | 1 |
| RTECS | LQ3000000 |
| TSCA | Yes |
| PackingGroup | II |
| HS Code | 29241990 |
| Hazardous Substances Data | 123-39-7(Hazardous Substances Data) |
| Toxicity | LD50 in mice (mg/kg): 2300 i.p.; 2600 orally; 1580 i.v.; 2700 i.m. (Langdon) |
Product Application
N-methylformamide is a vital organic chemical feedstock and intermediate. As a high-performance organic solvent, it is extensively employed in chemical synthesis procedures.
It is frequently adopted for synthesizing high-efficiency, low-toxicity monomethylformamide derivatives and distyrylamide compounds. Moreover, it can function as both a reaction medium and a purification solvent in organic synthesis.
This compound also finds wide-ranging applications in the pharmaceutical, dye, fragrance, electrolysis and electroplating industries, presenting considerable industrial utilization value.
